Apidaecin IB is an insect antimicrobial peptide showing a significant sequence homology and a common mechanism of action with drosocin, but is devoid of any pore-forming activity. Apidaecins are the most prominent components of the honey bee humoral defense against microbial invasion.
Casteels-Josson, K. et al. EMBO J. 12, 1569 (1993); Gobbo, M. et al. J. Med. Chem. 45, 4494 (2002).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Gly - Asn - Asn - Arg - Pro - Val - Tyr - Ile - Pro - Gln - Pro - Arg - Pro - Pro - His - Pro - Arg - Leu - OH