This peptide belongs to the acetylated cardiac alpha-myosin amino acid residues 614 to 643. Immunization with cardiac myosin induces T cell-mediated myocarditis in genetically predisposed mice and serves as a model for autoimmune heart disease. The nonacetylated variant of this dominant peptide corresponding to amino acids 614 to 643 fails to induce the disease. N-terminal acetylation significantly changes the pathogenicity of the peptides. This acetylated form of the peptide shows dominant pathogenicity and induces severe myocarditis with inflammatory lesions throughout the ventricular wall.
Pummerer, C. et al. J. Clin. Invest. 97, 2057 (1996).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
Ac - Ser - Leu - Lys - Leu - Met - Ala - Thr - Leu - Phe - Ser - Thr - Tyr - Ala - Ser - Ala - Asp - Thr - Gly - Asp - Ser - Gly - Lys - Gly - Lys - Gly - Gly - Lys - Lys - Lys - Gly - OH