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Peptides  >  Myosin  >>  Alpha-Myosin (614-643)

Product Name Alpha - Myosin (614 - 643)
Ac - SLKLMATLFSTYASADTGDSGKGKGGKKKG
Size 1 mg
Catalog # 62126
US$ $237
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide belongs to the acetylated cardiac alpha-myosin amino acid residues 614 to 643. Immunization with cardiac myosin induces T cell-mediated myocarditis in genetically predisposed mice and serves as a model for autoimmune heart disease. The nonacetylated variant of this dominant peptide corresponding to amino acids 614 to 643 fails to induce the disease. N-terminal acetylation significantly changes the pathogenicity of the peptides. This acetylated form of the peptide shows dominant pathogenicity and induces severe myocarditis with inflammatory lesions throughout the ventricular wall.

Storage -20C
References Pummerer, C. et al. J. Clin. Invest. 97, 2057 (1996).
Molecular Weight 3047.5
Sequence
(One-Letter Code)
Ac-SLKLMATLFSTYASADTGDSGKGKGGKKKG
Sequence
(Three-Letter Code)
Ac - Ser - Leu - Lys - Leu - Met - Ala - Thr - Leu - Phe - Ser - Thr - Tyr - Ala - Ser - Ala - Asp - Thr - Gly - Asp - Ser - Gly - Lys - Gly - Lys - Gly - Gly - Lys - Lys - Lys - Gly - OH
     
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