This peptide belongs to the acetylated cardiac alpha-myosin amino acid residues 614 to 643. Immunization with cardiac myosin induces T cell-mediated myocarditis in genetically predisposed mice and serves as a model for autoimmune heart disease. The nonacetylated variant of this dominant peptide corresponding to amino acids 614 to 643 fails to induce the disease. N-terminal acetylation significantly changes the pathogenicity of the peptides. This acetylated form of the peptide shows dominant pathogenicity and induces severe myocarditis with inflammatory lesions throughout the ventricular wall.
Storage
-20°C
References
Pummerer, C. et al. J. Clin. Invest. 97, 2057 (1996).
Molecular Weight
3047.5
Sequence (One-Letter Code)
Ac-SLKLMATLFSTYASADTGDSGKGKGGKKKG
Sequence (Three-Letter Code)
Ac - Ser - Leu - Lys - Leu - Met - Ala - Thr - Leu - Phe - Ser - Thr - Tyr - Ala - Ser - Ala - Asp - Thr - Gly - Asp - Ser - Gly - Lys - Gly - Lys - Gly - Gly - Lys - Lys - Lys - Gly - OH
