This cell-soluble high affinity-binding peptide, the RI anchoring disruptor (RIAD) selectively uncouples cAMP-mediated inhibition of T cell function and inhibits progesterone synthesis at the mitochondria in steroid-producing cells. These processes are controlled by the type I PKA holoenzyme and RIAD, and can be used as a tool to define anchored type I PKA signaling events.
Carlson, SR. et al. J. Biol. Chem. 281, 21535 (2006).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Leu - Glu - Gln - Tyr - Ala - Asn - Gln - Leu - Ala - Asp - Gln - Ile - Ile - Lys - Glu - Ala - Thr - Glu - Lys(FAM) - NH2