This peptide, with amino acids 63 to 79, is a fragment of the myelin basic protein and is the dominant encephalitogenic peptide for DA rats. Rats develop experimental autoimmune encephalomyelitis (EAE) after the immunization with this peptide. This sequence was also used in the research attempts to prevent EAE with neutralizing antibodies to IFN-gamma-Inducing Factor.
Storage
-20°C
References
Lenz, D. et al. J. Immunol. 163, 1763 (1999); Wildbaum, G. et al. J. Immunol. 161, 6368 (1998), Swanborg, R. Immunol. Rev 184, 129 (2001).
Molecular Weight
1645.1
Sequence (One-Letter Code)
ARTTHYGSLPQKSQRSQ
Sequence (Three-Letter Code)
H - Ala - Arg - Thr - Thr - His - Tyr - Gly - Ser - Leu - Pro - Gln - Lys - Ser - Gln - Arg - Ser - Gln - OH
