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Peptides  >  Myelin Oligodendrocyte Glycoprotein (MOG)/Myelin Basic Proteins (MBP)  >>  MBP (6381), Myelin Basic Protein (6381)

Product Name MBP (6381), Myelin Basic Protein (6381)
ARTTHYGSLPQKSQRSQ
Size 1 mg
Catalog # AS-62082
US$ $105
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide, with amino acids 63 to 79, is a fragment of the myelin basic protein and is the dominant encephalitogenic peptide for DA rats. Rats develop experimental autoimmune encephalomyelitis (EAE) after the immunization with this peptide. This sequence was also used in the research attempts to prevent EAE with neutralizing antibodies to IFN-gamma-Inducing Factor.

Storage -20C
References Lenz, D. et al. J. Immunol. 163, 1763 (1999); Wildbaum, G. et al. J. Immunol. 161, 6368 (1998), Swanborg, R. Immunol. Rev 184, 129 (2001).
Molecular Weight 1645.1
Sequence
(One-Letter Code)
ARTTHYGSLPQKSQRSQ
Sequence
(Three-Letter Code)
H - Ala - Arg - Thr - Thr - His - Tyr - Gly - Ser - Leu - Pro - Gln - Lys - Ser - Gln - Arg - Ser - Gln - OH
Product Citations Belogurov, A. et al. (2013). Liposome-encapsulated peptides protect against experimental allergic encephalitis. FASEB J 27, 222. doi: 10.1096/fj.12-213975.
Abourbeh, G. et al. (2013). Imaging microglial/macrophage activation in spinal vords of experimental autoimmune encephalomyelitis rats by positron emission tomography using the mitochondrial 18 kDa translocator protein radioligand [18F]DPA-714. J Neurosci 32, 5728. doi: 10.1523/​JNEUROSCI.2900-11.2012.
     
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