HRP Prorenin, Decoy Handle Region (31 - 40), rat RILLKKMPSV
% Peak Area By HPLC ≥ 95%
This peptide is a (pro)renin antagonist corresponding to the handle region of the prorenin prosegment (handle region peptide- HRP) also referred to as the decoy-peptide epitope corresponding to the 10-19 amino acid residues. A pathogenic role for preorenin in the retina has been suggested by studies and is under investigation based on its elevation in the plasma and vitreous of patients with diabetic retinopathy. The HRP could prevent binding of renin and prorenin to the prorenin receptor inhibitor and has potential beneficial effects in conditions including diabetic glomerulosclerosis, cardiac fibrosis and ocular pathology.