This peptide belongs to the Bcl-2 family of proteins. Noxa gene encodes a Bcl-2 homology 3 (BH3)-only member of this family; it contains the BH3 region, not other BH domains. When ectopically expressed, Noxa undergoes BH3 motif-dependent localization to mitochondria, it interacts with anti-apoptotic Bcl-2 family members resulting in the activation of caspase-9.
H - Pro - Ala - Glu - Leu - Glu - Val - Glu - Cys - Ala - Thr - Gln - Leu - Arg - Arg - Phe - Gly - Asp - Lys - Leu - Asn - Phe - Arg - Gln - Lys - Leu - Leu - OH
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