This 13-amino acid TIF2 peptide with a LxxLL motif is derived from the NR box2 region of TIF2 (SRC2–2). A short consensus motif, so-called nuclear receptor (NR) box, mediates ligand-dependent activation interaction function between nuclear receptors and their coregulators. This TIF2 peptide fragment is sufficient to interact with thyroid hormone ligand binding domain, TR-beta- LBD.
Kong, E. et al. PNAS 102, 3593 (2005); Wärnmark, A., et al. J. Biol. Chem. 277, 21862 (2002); Darimont, B. et al. Genes Dev. 12, 3343 (1998).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Glu - Lys - His - Lys - Ile - Leu - His - Arg - Leu - Leu - Gln - Asp - Ser - OH