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Peptides  >  Amylin Peptides  >>  [NMeG24, NMeI26] Human Islet Amyloid Polypeptide (IAPP) (22-27)

Product Name [NMeG24, NMeI26] Human Islet Amyloid Polypeptide (IAPP) (22 - 27)
NF - (NMe - G) - A - (NMe - I) - L
Size 1 mg
Catalog # 61937
US$ $220
Purity % Peak Area By HPLC ≥ 95%
Description

This amino acids 22 to 27 fragment is a modification of the human islet amyloid polypeptide hIAPP (NFGAIL) with N-methylation of the amide bonds at G24 and I26. The introduction of two N-methyl rests in the amyloid-core-containing sequence NFGAIL converts this amyloidogenic and cytotoxic sequence into non-amyloidogenic and non-cytotoxic peptide. The peptide is able to bind with high-affinity full-length hIAPP and to inhibit its fibrillogenesis.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20C
References Yan, L. et al. PNAS 103, 2046 (2006), Kapurniotu, A., et al. J. Mol. Biol. 315, 339 (2002), Tatarek-Nossol, M. et al. Cell Press 12, 797 (2005).
Molecular Weight 661.8
Sequence
(One-Letter Code)
NF-(NMe-G)-A-(NMe-I)-L
Sequence
(Three-Letter Code)
H - Asn - Phe - (NMe - Gly) - Ala - (NMe - Ile) - Leu - OH
     
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