This peptide is an innate defense regulator (IDR-1). IDR-1 acts through mitogen-activated protein kinase and other signaling pathways, enhances levels of monocyte chemokines while reducing pro-inflammatory cytokine responses. IDR-1 counters infection by selective modulation of innate immunity. It is protective against Gram-positive and Gram-negative pathogens in mouse models of infection.
Scott, M. et al. Nat. Biotechnol. 25, 465 (2007).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Lys - Ser - Arg - Ile - Val - Pro - Ala - Ile - Pro - Val - Ser - Leu - Leu - OH