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Peptides  >  Apoptosis Peptides  >>  PUMA BH3

Product Name PUMA BH3
EEQWAREIGAQLRRMADDLNAQYER
Size 1 mg
Catalog # AS-62404
US$ $198
Purity % Peak Area By HPLC ≥ 95%
Description

This is a PUMA (p53 upregulated modulator of apoptosis) BH3 domain peptide. PUMA together with Bcl-xL, and cytoplasmic p53 coordinates p53 functions. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome C release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.

Storage -20C
References Chipuk, J. et al. Science 309, 1732 (2005), Nakano, K. et al. Mol. Cell 7, 683 (2001), Yu, J. et al. Mol. Cell 7, 673 (2001), Han, J. et al. Proc. Natl. Acad. Sci. U S A. 98, 11318 (2001).
Molecular Weight 3049.3
Sequence
(One-Letter Code)
EEQWAREIGAQLRRMADDLNAQYER
Sequence
(Three-Letter Code)
H - Glu - Glu - Gln - Trp - Ala - Arg - Glu - Ile - Gly - Ala - Gln - Leu - Arg - Arg - Met - Ala - Asp - Asp - Leu - Asn - Ala - Gln - Tyr - Glu - Arg - OH
Product Citations Chipuk, J. et al. (2008). Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins. PNAS 105, 20327.
     
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