This peptide is amino acids 17 to 26 fragment of p53, the Mdm-2 binding domain of p53 known also as p53N. This sequence contains all of the residues that contact the binding domain of Mdm-2. The tumor suppressor protein p53 is important in maintaining genome stability and in preventing cancer development.
Wang, Y. et al. J. Biol. Chem. 281, 24803 (2006), Kanovsky, M. et al. PNAS 98, 12438 (2001).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Glu - Thr - Phe - Ser - Asp - Leu - Trp - Lys - Leu - Leu - OH