This peptide is amino acids 17 to 26 fragment of p53, the Mdm-2 binding domain of p53 known also as p53N. This sequence contains all of the residues that contact the binding domain of Mdm-2. The tumor suppressor protein p53 is important in maintaining genome stability and in preventing cancer development.
Storage
-20°C
References
Wang, Y. et al. J. Biol. Chem. 281, 24803 (2006), Kanovsky, M. et al. PNAS 98, 12438 (2001).
Molecular Weight
1251.5
Sequence (One-Letter Code)
ETFSDLWKLL
Sequence (Three-Letter Code)
H - Glu - Thr - Phe - Ser - Asp - Leu - Trp - Lys - Leu - Leu - OH
