This BAD peptide is biotinylated at the N-terminus through 6-aminohexanoate (LC) as a spacer. Bad peptide is a pro-apoptotic member of the Bcl2 family. Dephosphorylated Bad forms heterodimers with Bcl-XL and Bcl-2, blocking their anti-apoptotic effects. Inactive Bad is phosphorylated at Ser112, Ser136, and Ser155. The phosphorylation status of Bad represents a fundamental checkpoint for apoptotic death or cell survival.
Ciornei, R. and McGillis, J. J. Immunol. 178, S117 (2007).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
BIOTIN - LC - Ala - Gly - Ala - Gly - Arg - Ser - Arg - His - Ser - Ser - Tyr - Pro - Ala - Gly - Thr - OH