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Peptides  >  Cancer Research Peptides  >>  [pThr145]-p21 (140-147)

Product Name [pThr145] - p21 (140 - 147)
RKRRQ - pT - SM
Size 1 mg
Catalog # 62613
US$ $165
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide, amino acids 140 to 147 fragment of p21, is phosphorylated on Thr145. Pim-1 can efficiently phosphorylate p21 on Thr145 in vitro. Pim-1 is a serine/threonine kinase involved in the transduction of cytokine-triggered mitogenic signals. When p21 is phosphorylated on Thr145, it localizes to the nucleus and causes the disruption of the association between proliferating cell nuclear antigen and p21. Phosphorylation of Thr145 promotes stabilization of p21.

Storage -20C
References Zhang, Y. et al. Mol. Cancer Res. 5, 909 (2007), Mochizuki, T. et al. J. Biol. Chem. 274, 18659 (1999).
Molecular Weight 1142.3
Sequence
(One-Letter Code)
RKRRQ-pT-SM
Sequence
(Three-Letter Code)
H - Arg - Lys - Arg - Arg - Gln - pThr - Ser - Met - OH
     
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