[pSer155]-BAD BH3 (146-159)

Product Name	[pSer155] - BAD BH3 (146 - 159)
Size	1 mg
Catalog #	62482
US$	$165
Molecular Weight	1924.1
Sequence (One-Letter Code)	RYGRELRRM-pS-DEFE
Sequence (Three-Letter Code)	H - Arg - Tyr - Gly - Arg - Glu - Leu - Arg - Arg - Met - pSer - Asp - Glu - Phe - Glu - OH
Description	This is amino acids 146 to 159 fragment of BAD BH3 protein, phosphorylated at Ser155. Phosphorylation of BAD at Ser155 within the BH3 domain is a mechanism that inhibits the death-promoting activity of BAD. Protein kinase A, RSK1, and survival factor signaling stimulate phosphorylation of BAD at Ser155, blocking the binding of BAD to Bcl-XL. RSK1 may also phosphorylate BAD at Ser112 and Ser155 and rescue BAD-mediated cell death in a manner dependent upon phosphorylation at both sites.
References	Tan, Y. et al. J. Biol. Chem. 275, 25865 (2000).
Storage	-20°C
Detailed Information	Material Safety Data Sheets (MSDS)