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Peptides  >  Cell Permeable Peptides (CPP) / Drug Delivery Peptides  >>  Chimeric Rabies Virus Glycoprotein Fragment (RVG-9R)

Product Name Chimeric Rabies Virus Glycoprotein Fragment (RVG - 9R)
YTIWMPENPRPGTPCDIFTNSRGKRASNGGGGRRRRRRRRR
Size 1 mg
Catalog # 62565
US$ $484
Description

This chimeric peptide is a fragment derived from rabies virus glycoprotein (RVG). Because neurotropic viruses cross the blood-brain barrier to infect brain cells, the same strategy may be used to enter the central nervous system and deliver siRNA to the brain. To enable siRNA binding, this chimeric peptide was synthesized by adding nonamer arginine residues at the carboxy terminus of RVG. This RVG-9R peptide was able to bind and transduce siRNA to neuronal cells in vitro, resulting in efficient gene silencing. After intravenous injection into mice, RVG-9R delivered siRNA to the neuronal cells, resulting in specific gene silencing within the brain. RVG-9R provides a safe and noninvasive approach for the delivery of siRNA and potentially other therapeutic molecules across the blood–brain barrier.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20°C
References Kumar, P. et al. Nature 448, 39 (2007).
Molecular Weight 4843.5
Sequence
(One-Letter Code)
YTIWMPENPRPGTPCDIFTNSRGKRASNGGGGRRRRRRRRR
Sequence
(Three-Letter Code)
H - Tyr - Thr - Ile - Trp - Met - Pro - Glu - Asn - Pro - Arg - Pro - Gly - Thr - Pro - Cys - Asp - Ile - Phe - Thr - Asn - Ser - Arg - Gly - Lys - Arg - Ala - Ser - Asn - Gly - Gly - Gly - Gly - Arg - Arg - Arg - Arg - Arg - Arg - Arg - Arg - Arg - OH
     
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