This peptide is the mastoparan modification with Leu3 to Trp3, Ala5 to Gly5, Leu6 to Ile6, Leu9 to Met9, Ile13 to Leu13, referred as mastoparan X (MPX). Mastoparan is an amphiphilic tetradecapeptide isolated from wasp venom. It is known to possess a variety of biological activities including mast cell degranulation, mobilization of Ca2+ from cerebellar microsomes and sarcoplasmic reticulum, and modulation of various enzymes. This mastoparan analog, MPX, as well as mastoparan 7 (MP7), has similar effects on ATPase activity as mastoparan itself. The ability of mastoparan analogs to interact with the Ca2+-ATPase and inhibit it, correlates with their ability to adopt ordered conformations in membranes as well as their amphiphilicity.
Longland, C. et al. J. Biol. Chem. 274, 14799 (1999).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ile - Asn - Trp - Lys - Gly - Ile - Ala - Ala - Met - Ala - Lys - Lys - Leu - Leu - NH2