This peptide is the mastoparan modification with Leu3 to Trp3, Ala5 to Gly5, Leu6 to Ile6, Leu9 to Met9, Ile13 to Leu13, referred as mastoparan X (MPX). Mastoparan is an amphiphilic tetradecapeptide isolated from wasp venom. It is known to possess a variety of biological activities including mast cell degranulation, mobilization of Ca2+ from cerebellar microsomes and sarcoplasmic reticulum, and modulation of various enzymes. This mastoparan analog, MPX, as well as mastoparan 7 (MP7), has similar effects on ATPase activity as mastoparan itself. The ability of mastoparan analogs to interact with the Ca2+-ATPase and inhibit it, correlates with their ability to adopt ordered conformations in membranes as well as their amphiphilicity.
Storage
-20°C
References
Longland, C. et al. J. Biol. Chem. 274, 14799 (1999).
Molecular Weight
1556
Sequence (One-Letter Code)
INWKGIAAMAKKLL-NH2
Sequence (Three-Letter Code)
H - Ile - Asn - Trp - Lys - Gly - Ile - Ala - Ala - Met - Ala - Lys - Lys - Leu - Leu - NH2
