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Peptides  >  FRET Peptides  >>  C2 substrate, (DABCYL/EDANS)

Product Name C2 substrate, (DABCYL/EDANS)
DABCYL - SLGRKIQI - EDANS
Size 1 mg
Catalog # AS-61317
US$ $181
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide is a second complement component (C2), the physiological substrate for the proenzyme Cls, first complement component. The C1 component is a complex of the binding protein C1q and two proenzymes, C1r and C1s. The C1s protease of the C1 complex initiates the host defense pathway cleaving the C4 and C2 components to instigate a sequence of activation steps of other components of the complement system, culminating in the formation of the membrane attack complex, which induces cell lysis. This peptide employs DABCYL / EDANS as FRET pair.

Storage -20C
References Kerr, F. et al. J. Biol. Chem. 280, 39510 (2005).
Molecular Weight 1413.7
Sequence
(One-Letter Code)
DABCYL -SLGRKIQI-EDANS
Sequence
(Three-Letter Code)
Dabcyl - Ser - Leu - Gly - Arg - Lys - Ile - Gln - Ile - EDANS
     
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