This peptide is the capsid derived immunodominant adeno-associated virus 2 (AAV2), CD8 T cell epitope. Liver toxicity observed in a clinical trial of AAV2 delivered systemically to patients with hemophilia was ascribed to killing of vector-transduced hepatocytes by capsid-specific T-cells.
Murphy, S. et al. Blood (ASH Annual Meeting Abstracts), 108 (2006), Mingozzi, F. et al. Nature Medicine 10.1038/nm1549 (2007), Wang, L. et al. Therapy. 18, 185 (2007).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Val - Pro - Gln - Tyr - Gly - Tyr - Leu - Thr - Leu - OH