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Peptides  >  MHC related   >>  IL-8 Inhibitor

Product Name IL - 8 Inhibitor
Ac - RRWWCR - NH2
Size 1 mg
Catalog # AS-62401
US$ $71
Purity % Peak Area By HPLC ≥ 95%
Description

This hexapeptide, acetylated on the amino terminus and amidated on the carboxyl terminus, inhibits the specific binding of 125I-IL-8 to neutrophils. IL-8 is a member of the chemokine alpha subfamily that activates neutrophils and is chemotactic for these cells. IL-8 Inhibitor also suppresses the binding of macrophage inflammatory protein 2 (MIP 2) beta to neutrophils.

Storage -20C
References Hayashi, S. et al. J. Immunol. 154, 814 (1995).
Molecular Weight 1003.2
Sequence
(One-Letter Code)
Ac-RRWWCR-NH2
Sequence
(Three-Letter Code)
Ac - Arg - Arg - Trp - Trp - Cys - Arg - NH2
Product Citations Agarwal, A. et al. (2011). Direct Elucidation of disulfide bond partners using ultraviolet photodissociation mass spectrometry. Anal Chem 83, 6455.
Hoth, JJ. et al. (2011). Mechanism of neutrophil recruitment to the lung after pulmonary contusion. Shock 35, 604.
Zerfaoui, M. et al. (2009). Effects of PARP-1 deficiency on airway inflammatory cell recruitment in response to LPS or TNF: differential effects on CXCR2 ligands and Duffy antigen receptor for chemokines. J Leukocyte Biol 86, 1385.
     
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