This is amino acids 81 to 111 fragment of the NY-ESO-1. The NY-ESO-1 antigen is expressed by many tumors of different histological types (including breast, prostate, lung, and melanoma) and by male germline cells, but not by other normal tissues. NY-ESO-1 encodes MHC class I- and class II-restricted peptides expressed by a diverse range of cancers and recognized by T cells. This peptide is pan-MHC class II-restricted sequence that is capable of binding to multiple HLA-DR and HLA-DP4 molecules, including HLA-DRB1*0101, 0401, 0701, and 1101 and HLA-DPB1*0401 and 0402 molecules.
Mandic, M. et al. J. Immunol. 174, 1751 (2005).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Leu - Leu - Glu - Phe - Tyr - Leu - Ala - Met - Pro - Phe - Ala - Thr - Pro - Met - Glu - Ala - Glu - Leu - Ala - Arg - Arg - Ser - Leu - Ala - Gln - OH