This octapeptide is amino acids 52 to 59 fragment of the the vesicular stomatitis virus (VSV) nucleoprotein. VSV-8 is derived from the VSV nucleoprotein that is expressed in the cytosol of the infected cells. CTL response against VSV in H-2Kb mice is directed against this single VSV-8 immunodominant peptide. This peptide forms complex with murine MHC class I molecule H-2Kb, which is similar to human HLA class I.
Fremont, D. et al. Science 257, 919 (1992), Brock, R. et al. PNAS 93, 13108 (1996), Nieland, T. et al. PNAS 93, 6135 (1996), Hin, S. et al. J. Biol. Chem. 276, 48790 (2001).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Arg - Gly - Tyr - Val - Tyr - Gln - Gly - Leu - OH