This is amino acids 92 to 106 fragment of the myelin oligodendrocyte glycoprotein (MOG). Mice with MOG (92–106)-induced experimental autoimmune encephalomyelitis develop extensive B cell reactivity against secondary myelin antigens. Despite the fact that this MOG peptide induces only weak T cell responses, MOG-induced autoimmunity is very severe. This peptide is encephalitogenic in SJL mice, DA rats, and rhesus monkeys.
Bischof, F. et al. J. Immunol. 173, 600 (2004).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Asp - Glu - Gly - Gly - Tyr - Thr - Cys - Phe - Phe - Arg - Asp - His - Ser - Tyr - Gln - OH