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Peptides  >  Prion Protein (PrP) Fragments  >>  PrP (166-179), Protease-Resistant Prion Protein (166-179) (Biotin-LC), hamster

Product Name PrP (166 - 179), Protease - Resistant Prion Protein (166 - 179) (Biotin - LC), hamster
Biotin - LC - VDQYNNQNNFVHDC
Size 1 mg
Catalog # 62111
US$ $121
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide potently inhibits the protease-resistant prion protein (PrP-res) induced cell-free conversion of protease-sensitive (PrP-sen) to the protease-resistant state. The formation of PrP-res involves selective interactions between PrP-res and its normal protease-sensitive counterpart, PrP-sen. The accumulation of the protease-resistant isoform of prion protein PrP-res in the central nervous system is the pre-eminent neuropathological feature of transmissible spongiform encephalopathies (TSEs), a fatal neurodegenerative disease. This inhibitory peptide may mimic contact surfaces between PrP-res and PrP-sen and thereby serve as model of potential therapeutic agent for transmissible spongiform encephalopathies. This peptide is biotinylated through 6-aminohexanoate (LC) as a spacer at the N-terminus.

Storage -20C
References Horiuchi, M. et al. J. Biol. Chem. 276, 15489 (2001).
Molecular Weight 2049.3
Sequence
(One-Letter Code)
Biotin-LC-VDQYNNQNNFVHDC
Sequence
(Three-Letter Code)
Biotin - LC - Val - Asp - Gln - Tyr - Asn - Asn - Gln - Asn - Asn - Phe - Val - His - Asp - Cys - OH
     
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