This peptide potently inhibits the protease-resistant prion protein (PrP-res) induced cell-free conversion of protease-sensitive (PrP-sen) to the protease-resistant state. The formation of PrP-res involves selective interactions between PrP-res and its normal protease-sensitive counterpart, PrP-sen. The accumulation of the protease-resistant isoform of prion protein PrP-res in the central nervous system is the pre-eminent neuropathological feature of transmissible spongiform encephalopathies (TSEs), a fatal neurodegenerative disease. This inhibitory peptide may mimic contact surfaces between PrP-res and PrP-sen and thereby serve as model of potential therapeutic agent for transmissible spongiform encephalopathies. This peptide is biotinylated through 6-aminohexanoate (LC) as a spacer at the N-terminus.
Horiuchi, M. et al. J. Biol. Chem. 276, 15489 (2001).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
Biotin - LC - Val - Asp - Gln - Tyr - Asn - Asn - Gln - Asn - Asn - Phe - Val - His - Asp - Cys - OH