This is amino acids 641 to 654 fragment of collagenous protein precursor, a component of senile plaque amyloid, designated as CLAC-P (collagenous Alzheimer amyloid plaque component)-precursor. It is a putative extracellular portion of CLAC-P/ColXXV. Immunoblotting of formic acid extracts of Alzheimers desease cortices with anti-NC4 showed the major positive band migrating at 70 kDa.
Osada, Y. et al. J. Biol. Chem. 280, 8596 (2005); Hashimoto, T. et al. EMBO J. 21, 1524 (2002)
Sequence (One-Letter Code)
LGPDGLPMPGCWQK regions of CLAC-P
Sequence (Three-Letter Code)
H - Leu - Gly - Pro - Asp - Gly - Leu - Pro - Met - Pro - Gly - Cys - Trp - Gln - Lys - OH