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Recombinant Proteins  >  HCV (Hepatitis C Virus)  >>  HCV NS3/4A protease mutant V170A, recombinant

Product Name HCV NS3/4A protease mutant V170A, recombinant
Size 5 g
Catalog # AS-72035-5
US$ $247
Description

The Hepatitis C Virus (HCV) NS3/4A serine protease is essential for viral replication and the formation of infectious viral particles, and thus has been considered as one of the most attractive targets for anti-HCV therapy. Due to poor fidelity of viral reverse transcriptase and RNA-dependent RNA polymerase, drug resistant mutations emerge rapidly against protease inhibitors. Three mutations, V170A, T54A, and A156S, were identified to confer low to moderate levels of resistance (<20-fold) to HCV NS3/4A protease inhibitor SCH503034.

The recombinant HCV NS3/4A protease mutant V170A is derived from its wild type (NCBI Accession: CAB46913) with a substitution of Val170 with Ala. It is a 217 amino acid fusion protein with NS3 protease domain and a fragment of the NS4A protein fused to its N-terminus.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -80C
     
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