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Peptides  >  Histones  >  Histone H4 Peptides  >>  [Lys(Ac)8]-Histone H4 (1-20), H4K8(Ac)

Product Name [Lys(Ac)8] - Histone H4 (1 - 20), H4K8(Ac)
SGRGKGG - K(Ac) - GLGKGGAKRHRK
Size 1 mg
Catalog # AS-63684
US$ $181
Purity % Peak Area By HPLC ≥ 95%
Description

This is a histone 4 peptide acetylated at lysine 8. In some studies, this histone modification is thought to predict prognosis of resected non-small-cell lung cancer. This peptide has also been shown to play a role in somatic hypermutation (SHM) possible owing to its modification that likely mediates recruitment of error-prone DNA polymerases at the DNA repair stage of SHM.

Storage -20C
References 1, Borra, MT. et al. Biochem. 43, 9877 (2004)
2, Barlesi F. et al. J Clin Oncol, 25(28):4358-4364 (2007)
3, Guideng Li. Et al. Trends Immunol, 34(9):460-470 (2013).
Molecular Weight 2034.4
Sequence
(One-Letter Code)
SGRGKGG-K(Ac)-GLGKGGAKRHRK
Sequence
(Three-Letter Code)
H - Ser - Gly - Arg - Gly - Lys - Gly - Gly - Lys(Ac) - Gly - Leu - Gly - Lys - Gly - Gly - Ala - Lys - Arg - His - Arg - Lys - OH
     
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