This peptide is Histone 4 acetylated at lysine 12. Based on genome-wide localization studies, this peptide has been found to occupy promoter region at the transcription start sites, especially being associated with particular promoters that may drive high levels of mRNA transcripts stored in mature spermatozoa. Such observations have led to assumptions that H4K12Ac may be one of the epigenetic marks for developmentally important genes.
1, Borra, MT. et al. Biochem. 43, 9877 (2004) 2, Paradowska AS. et al. Epigen, 7(9):1057-70 (2012).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Gly - Arg - Gly - Lys - Gly - Gly - Lys - Gly - Leu - Gly - Lys(Ac) - Gly - Gly - Ala - Lys - Arg - His - Arg - Lys - OH