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Peptides  >  Histones  >  Histone H3 Peptides  >>  [Lys(Me3)9]-Histone H3 (1-24), H3K9(Me3)

Product Name [Lys(Me3)9] - Histone H3 (1 - 24), H3K9(Me3)
ARTKQTAR - K(Me3) - STGGKAPRKQLATKA
Size 0.5 mg
Catalog # AS-63679
US$ $181
Purity % Peak Area By HPLC ≥ 95%
Description

This Histone 3 peptide is trimethylated at lysine residue at the 9th position and constitutes as a repressive histone methylation marker. This peptide and DNA methylation have been shown to regulate distinct set of genes, chimeric transcripts and retroelements in mouse embryonic stem cells. Variations of histone methylation markers have been reported in cancer, and this peptide was shown to be upregulated in breast cancer and down regulated in colorectal cancer.

Detailed Information Datasheet
Storage -20C
References 1, Karimi MM. et al. Cell Stem Cell. 8(6):676-687 (2011).
2, Leszinski G. et al. Antican Res. 32(5(:2199-2205 (2012).
Molecular Weight 2597.0
Sequence
(One-Letter Code)
ARTKQTAR-K(Me3)-STGGKAPRKQLATKA
Sequence
(Three-Letter Code)
H - Ala - Arg - Thr - Lys - Gln - Thr - Ala - Arg - Lys(Me3) - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - Thr - Lys - Ala - OH
Product Citations Brauchle, M. et al. (2013). Protein complex interactor analysis and differnetial activity of KDM3 subfamily members towards H3K9 methylation. PLOS one84:e60549. doi:10.1371/journal.pone.0060549.
     
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