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Peptides  >  Amyloid Peptides  >  Amyloid Toxicity Inhibitor Peptides  >>  Amyloid Toxicity Inhibitor Peptide 110

Product Name Amyloid Toxicity Inhibitor Peptide 110
RGTWEGKW - NH2
Size 1 mg
Catalog # 62837
US$ $71
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide is a modification of the amyloid toxicity inhibitor peptide 11 with Trp4 and Trp8 replacing Gly4 and Gly8 of the original peptide. This peptide is highly effective in blocking beta-amyloid 1 to 40 fibrillization. It is the most effective inhibitor among the amyloid toxicity inhibitor peptides group. The observation that the peptide 110 is able to depolymerize mature b-amyloid 1 to 40 supports the view that these are dynamic structures and suggests that targeting beta-sheet packing may be an effective strategy for depolymerizing amyloid plagues.

Storage -20C
References Sato, T. et al. Biochem. 45, 5509 (2006).
Molecular Weight 1018.2
Sequence
(One-Letter Code)
RGTWEGKW-NH2
Sequence
(Three-Letter Code)
H - Arg - Gly - Thr - Trp - Glu - Gly - Lys - Trp - NH2
     
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