This peptide is the mutant form of the b-Amyloid peptide (1-40). The mutation within the coding region of the ß-Amyloid precursor protein (APP) results in substitution of glycine for alanine in this peptide. Presenile dementia is present in a pattern consistent in the family of British origin with the dominant inheritance of Flemish APP mutation. The impact of the point mutation A21G on b-Amyloid structure and dynamics varies from b-Amyloid (1-40) to b-Amyloid (1-42).
Brooks, W. et al. Neurol.63, 1613 (2004); Van Nostrand, W. et al. J. Biol. Chem.276, 32860 (2001); A. Huet and P. Derreumaux Biophys. J.91, 3829 (2006).
Molecular Weight
4315.9
Sequence (One-Letter Code)
DAEFRHDSGYEVHHQKLVFFGEDVGSNKGAIIGLMVGGVV
Sequence (Three-Letter Code)
H - Asp - Ala - Glu - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - Val - His - His - Gln - Lys - Leu - Val - Phe - Phe - Gly - Glu - Asp - Val - Gly - Ser - Asn - Lys - Gly - Ala - Ile - Ile - Gly - Leu - Met - Val - Gly - Gly - Val - Val - OH
Material Safety Data Sheets (MSDS)
