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| Product Name |
Amylin(20 - 29), Islet Amyloid Polypeptide, IAPP (20 - 29), cat |
| Size |
1 mg |
| Catalog # |
62763 |
| US$ |
$70 |
| Molecular Weight |
1019.1 |
Sequence
(One-Letter Code) |
SNNFGAILSP |
Sequence
(Three-Letter Code) |
H - Ser - Asn - Asn - Phe - Gly - Ala - Ile - Leu - Ser - Pro - OH |
| Description |
This is amino acids 20 to 29 fragment of the cat islet amyloid polypeptide (IAPP), or amylin 20 to 29. Only a small number of animal species is known to show amyloidogenesis. These include human and nonhuman primates, cats, and raccoons, with this segment being important for amyloid formation. IAPP, a putative polypeptide hormone, is a product of pancreatic beta-cells and the major constituent of the amyloid deposits seen mainly in islets of type 2 diabetic humans and diabetic cats. The NFGAIL sequence, amino acid residues 22 to 27, forms aggregates similar to those of the entire IAPP. IAPP has been increasingly studied as a simple model for factors governing amyloid fibril formation. |
| References |
Zanuy, D. et al. Biophys. J. 84, 1884 (2003); Westermark, P. et al. Proc. Natl. Acad. Sc. 87, 5036 (1990). |
| Storage |
-20°C |
| Detailed Information |
 Material Safety Data Sheets (MSDS)
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