Islet amyloid polypeptide (hIAPP) fragment 22 to 27 is sufficient for the formation of beta-sheet-containing amyloid fibrils. These fibrils self-assemble and coil around each other in a typical amyloid fibril morphology. This peptide may assist in the rational design of inhibitors of pancreatic amyloid formation or other amyloidosis-related diseases.
Storage
-20°C
References
Gazit, E. FEBS J.272, 5971 (2005); Tenidis, K. et al. J. Mol. Biol.295, 1055 (2000); Yan, L. et al. Proc. Natl. Acad. Sc.103, 2046 (2006); Wu, C. et al. Biophys. J.87, 3000 (2004).
