This cyclic peptide is designed to mimic the most critical tumor necrosis factor (TNF) recognition loop on TNF receptor I. It prevents interactions of TNF with its receptor. This TNF antagonist is a useful template for the development of small molecular inhibitors to prevent both inflammatory bone destruction and systemic bone loss in rheumatoid arthritis.
Storage
-20°C
References
Saito, H. et al. Arthritis Rheum.56, 1164 (2007).
Molecular Weight
1226.4
Sequence (One-Letter Code)
YCWSQYLCY (Disulfide bridge: 2-8)
Sequence (Three-Letter Code)
H - Tyr - Cys - Trp - Ser - Gln - Tyr - Leu - Cys - Tyr - OH (Disulfide bridge: 2 - 8)
