This is amino acids 91 to 108 fragment of the rat myelin oligodendrocyte glycoprotein (MOG). Rats immunized with this peptide induce severe experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis (MS), and also demyelinating lesions. This peptide also proved to be a linear B cell determinant.
Weissert, R. et al. J. Immunol.166, 7588 (2001).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Asp - Glu - Gly - Gly - Tyr - Thr - Cys - Phe - Phe - Arg - Asp - His - Ser - Tyr - Gln - Glu - Glu - OH