This is a mutated β-Amyloid 1 to 28 amino acids sequence in which the KLVFF sequence (Ab16-20) is substituted with AAVFA. The KLVFF is the shortest peptide displaying consistent high binding capacity to full-length Aβ. The first, second, and fifth residues (i.e. KLXXF) are critical for binding. The substitutions in this Aβ (1-28) amino acids sequence in the 16 to 20 region profoundly impair the ability of the peptide to aggregate and form amyloid-like fibrils.
Tjernberg, L. et al. J. Biol. Chem.271, 8545 (1996).
Molecular Weight
3087.2
Sequence (One-Letter Code)
DAEFRHDSGYEVHHQAAVFAAEDVGSNK
Sequence (Three-Letter Code)
H - Asp - Ala - Glu - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - Val - His - His - Gln - Ala - Ala - Val - Phe - Ala - Ala - Glu - Asp - Val - Gly - Ser - Asn - Lys - OH
Material Safety Data Sheets (MSDS)
