[Ala16,17,20] - β - Amyloid (1 - 28), Human DAEFRHDSGYEVHHQAAVFAAEDVGSNK
% Peak Area By HPLC ≥ 95%
This is a mutated b-Amyloid 1 to 28 amino acids sequence in which the KLVFF sequence (Ab16-20) is substituted with AAVFA. The KLVFF is the shortest peptide displaying consistent high binding capacity to full-length Ab. The first, second, and fifth residues (i.e. KLXXF) are critical for binding. The substitutions in this Ab (1-28) amino acids sequence in the 16 to 20 region profoundly impair the ability of the peptide to aggregate and form amyloid-like fibrils.