Aggrecanases are glutamyl-specific multidomain metalloproteinases of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. They hydrolyze aggrecan, the major proteoglycan of articular cartilage, causing osteoarthritis and other joint diseases. ADAMTS-1 has also been shown to cleave versican, which is the principal large proteoglycan expressed in mid-tendon. Human recombinant ADAMTS-1 is highly active and can be used as a positive control in FRET-based and aggrecan enzyme activity assays, Western blot, IP, and ELISA.
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