Isolated originally from pig intestine, this proline and arginine rich 39 amino acid peptide is also found in neutrophil azurophilic granules and macrophages. This peptide plays a role in cell motility and metastatic potential in wound repair; binds to NADPH oxidase complex protein p47phox7 and a signaling adaptor protein p130Cas. And recently, PR39 is found to inhibit hypoxia-induced apoptosis and decrease caspase-3 activity in endothelial cells.
Wu, J. et al. Circulation109, 1660 (2004).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Arg - Arg - Arg - Pro - Arg - Pro - Pro - Tyr - Leu - Pro - Arg - Pro - Arg - Pro - Pro - Pro - Phe - Phe - Pro - Pro - Arg - Leu - Pro - Pro - Arg - Ile - Pro - Pro - Gly - Phe - Pro - Pro - Arg - Phe - Pro - Pro - Arg - Phe - Pro - OH