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Peptides  >  Cell Adhesion Peptides  >>  43Gap 26, Connexin Mimetic

Product Name 43Gap 26, Connexin Mimetic
VCYDKSFPISHVR
Size 1 mg
Catalog # AS-62644
US$ $83
Purity % Peak Area By HPLC ≥ 95%
Description

This Gap 26 peptide is derived from the first extracellular loop sequence of connexin (Cx) 43. This short mimetic peptide reversibly inhibits the gap junction-dependent propagation of Ca2+ waves between tracheal airway epithelial cells. Connexins, or gap junctions, are a family of structurally-related transmembrane proteins. Gap junctions contain channels that allow the passage of ions and small molecules between adjacent cells molecules. Calcium and inositol phosphates are among the second messengers that can pass through gap junction channels.

Storage -20C
References Boitano, S. and H. Evans Am. J. Physiol. Lung Cell Mol. Physiol. 279, L623 (2000).
Molecular Weight 1550.8
Sequence
(One-Letter Code)
VCYDKSFPISHVR
Sequence
(Three-Letter Code)
H - Val - Cys - Tyr - Asp - Lys - Ser - Phe - Pro - Ile - Ser - His - Val - Arg - OH
Product Citations Karpuk, N. et al. (2011). Neuroinflammation Leads to Region-Dependent Alterations in Astrocyte Gap Junction Communication and Hemichannel Activity. J Neurosci 31, 414.
     
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