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Peptides  >  Neuropeptides  >>  Neuropeptide S, NPS (1-10), rat

Product Name Neuropeptide S, NPS (1 - 10), rat
SFRNGVGSGV
Size 1 mg
Catalog # AS-62599
US$ $71
Purity % Peak Area By HPLC ≥ 95%
Description

This is amino acids 1 to 10 fragment of rat neuropeptide S, rNPS, the endogenous ligand of an orphan G protein-coupled receptor (GPCR). Central administration of NPS promotes behavioral arousal and suppresses all stages of sleep in rodents. NPS may induce transient increases of intracellular Ca2+, indicating that it might have excitatory effects at the cellular level. NPS receptor can couple to intracellular Ca2+. The pharmacophore of NPS is contained within the N-terminal part of the peptide, and NPS 1 to 10 is a minimally active structure.

Storage -20C
References Reinscheid, R. et al. J. Pharmacol. Exp. Ther. 315, 1338 (2005).
Molecular Weight 979.1
Sequence
(One-Letter Code)
SFRNGVGSGV
Sequence
(Three-Letter Code)
H - Ser - Phe - Arg - Asn - Gly - Val - Gly - Ser - Gly - Val - OH
     
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