This is amino acids 721 to 770 fragment of the amyloid precursor protein resulting from the g-secretase cleavage of the C-terminus of beta-amyloid precursor protein (APP) at Leu720-Val721. This peptide is also known as CTF50-99. The mutation at Leu723 (L723P) causes familial Alzheimer’s disease.
Storage
-20°C
References
Gu, Y., et al. J. Biol. Chem.276, 35235 (2001); Kwok, J. et al. Ann. Neurol.47, 249 (2000).
H - Val - Met - Leu - Lys - Lys - Lys - Gln - Tyr - Thr - Ser - Ile - His - His - Gly - Val - Val - Glu - Val - Asp - Ala - Ala - Val - Thr - Pro - Glu - Glu - Arg - His - Leu - Ser - Lys - Met - Gln - Gln - Asn - Gly - Tyr - Glu - Asn - Pro - Thr - Tyr - Lys - Phe - Phe - Glu - Gln - Met - Gln - Asn - OH
