This peptide is derived from tyrosinase-related protein 2 (TRP2) residues 180-188. TRP2 belongs to the melanocyte differentiation antigens and has been implicated as a target for immunotherapy of human as well as murine melanoma. Studies show that this TRP2 derived peptide can bind to mouse and human MHC class I molecules. Immunization with TRP2 peptide loaded dendritic cells (DCs) results in effective induction of antitumor immunity.
Park, J. et al. The EMBO J. 18, 3024 (1999); Bichsel, S. et al. J. Biol. Chem. 279, 35228 (2004)
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Val - Tyr - Asp - Phe - Phe - Val - Trp - Leu - OH