This glycopeptide is a MUC5AC peptide with two sites (Thr3 and Thr13) labeled with GalNAc, where the asterisk denotes GalNAc-modified residues. Mucin type O-linked glycosylation is initiated by the action of a family of UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferases (ppGaNTase), which catalyze the transfer of GalNAc from the nucleotide sugar UDP-GalNAc to the hydroxyl group of either serine or threonine.
Ten Hagen, K. et al. J. Biol. Chem.277, 22616 (2002).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Gly - Thr - Thr* - Pro - Ser - Pro - Val - Pro - Thr - Thr - Ser - Thr - Thr* - Ser - Ala - Pro - OH (Thr* labeled with GalNAc)