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Peptides  >  Cell Permeable Peptides (CPP) / Drug Delivery Peptides  >>  Pep-1-Cysteamine

Product Name Pep - 1 - Cysteamine
Ac - KETWWETWWTEWSQPKKKRKV - cysteamine
Size 1 mg
Catalog # 63849
US$ $193
Description

Pep-1 is one of the synthetic cell-penetrating peptides (CPPs), which has been successfully used to deliver a variety of proteins and other biopharmaceutical macromolecules into cells in a non-disruptive way. It is a CPP with primary amphipathicity (i.e amphipathicity resulting from the amino acid sequence itself, not from the folding structure) that comprises a tryptophan-rich so-called ‘hydrophobic’ domain, a hydrophilic domain derived from an NLS (nuclear localization signal) of SV40 (simian virus 40) large T-antigen, and a spacer between them. A cysteamine group is present at the C-terminus. The presence of cysteamine group in C terminal seems to play a crucial role in the delivery efficiency of cargoes into cells.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20°C
References Henriques, S. et al. FEBS Letters Vol. 579, 4498 (2005).
Molecular Weight 2950.3
Sequence
(One-Letter Code)
Ac-KETWWETWWTEWSQPKKKRKV-cysteamine
Sequence
(Three-Letter Code)
Ac - Lys - Glu - Thr - Trp - Trp - Glu - Thr - Trp - Trp - Thr - Glu - Trp - Ser - Gln - Pro - Lys - Lys - Lys - Arg - Lys - Val - cysteamine
Product Citations Bartz, R. et al. (2011). Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape. Biochem J doi:10.1042/BJ20101021.
     
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