This is one of the cell-penetrating peptides (CPPs) derived from the human immunodeficient virus (HIV)-1 Tat protein residue 48-60. It has been used to deliver exogenous macromolecules into cells in a non-disruptive way.
Dennison, S.R. et al. Biochem. and Biophy. Res. Comm. 363, 178 (2007); Futaki, S. Advanced Drug Delivery Rev. 57, 547 (2005)
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Gly - Arg - Lys - Lys - Arg - Arg - Gln - Arg - Arg - Arg - Pro - Pro - Gln - OH