The native peptide, GPHRSTPESRAAV (345-357) in human; (221-233) or (351-363) in mouse is a part of the hydrophilic loop domain of presenilin 1 that is selectively recognized by GSK-3β. This sequence is not recognized by p38α, p38β, PKC, or CK II.
Hirata, Y. et al. Mol. Biol. Cell 14, 302 (2003); Kirschenbaum, F. et al. J. Biol. Chem. 276, 7366 (2001).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
5 - TMR - Gly - Pro - His - Arg - Ser - Thr - Pro - Glu - Ser - Arg - Ala - Ala - Val - OH